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Using advanced XpresHAn Technology™, Restylane® Defyne can help tackle deep-set wrinkles, such as nasolabial folds and marionette lines. Its innovative cross-linked hyaluronic acid works to refresh your complexion, providing a more youthful yet still natural-looking visage, while preserving your natural likeness.
As we age our skin's elastic quality is reduced, causing the nasolabial folds (lines from the sides of the nose to the corners of the mouth) and the marionette lines (from mouth corners to chin) to become more visible. Restylane Defyne is developed using XpresHAn TechnologyTM to counteract these deepened lines.3 The particular way the gel is cross-linked in Defyne is also intended to support facial expressions and offer natural-looking results that keep your natural movement.
Restylane® Defyne is designed for mid-to-deep injection into facial tissue to correct moderate to severe wrinkles and folds, like nasolabial folds, for patients aged 21 and up.
Restylane® Defyne is a sterile, biodegradable gel composed of viscoelastic hyaluronic acid with a 20 mg/mL sodium hyaluronate concentration in phosphate buffered saline at pH 7, as well as 3 mg/mL of lidocaine hydrochloride. Its clear, colorless, homogeneous structure features a high lifting capacity.
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FAQs |
What is the Restylane family of products, and how are Restylane® Silk, Restylane® Lyft, Restylane®, Restylane® Refyne and Restylane® Defyne different? The Restylane family of dermal fillers is a range of hyaluronic acid products, including Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne, and Restylane Defyne. They are clear gel formulations of hyaluronic acid, a substance which replicates the hyaluronic acid naturally occurring in the body. Each Restylane product is tailored to a particular purpose. Restylane Silk is the first FDA-approved filler specifically developed to subtly augment the lips and smooth wrinkles around the mouth. Its gel is significantly smaller, smoother than other Restylane products, creating a softer, more precise outcome. These qualities make Restylane Silk a great option for restoring and perfecting the lips. Moreover, the ultrafine needle enables optimal accuracy and precision when administering the product. Approved by the FDA, Restylane Lyft is designed to improve volume in the back of the hands, augment cheeks, and address midface contour deficiencies associated with aging. Additionally, it is indicated to treat moderate to severe facial folds, including nasolabial folds (smile lines). Lyft is the only hyaluronic filler approved by the FDA to handle hands and faces, containing 0.3% lidocaine to reduce pain during the procedure. Restylane is clinically proven to add volume and fullness to the skin, reducing the appearance of moderate to severe facial wrinkles and folds like nasolabial folds. Additionally, Restylane is indicated for lip augmentation. Restylane Defyne contains a special formulation that smoothly fills in nasolabial folds and marionette lines, while remaining flexible enough to replicate natural facial movements and expressions. Restylane Defyne is designed to act like your body’s own hyaluronic acid to help smooth out deeper lines around your mouth (nasolabial folds and marionette lines)4 while letting you look more natural through a range of facial expressions. Restylane treatments are permissible only for individuals aged 21 or older. What are dermal fillers? What is hyaluronic acid? Dermal fillers are facial injection treatments used to help diminish wrinkles while restoring volume and fullness in the face and hands. There are several types of dermal fillers, one being hyaluronic acid. All Restylane products are transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness and elasticity. What causes wrinkles? As we age, our skin thins and loses natural fat, leading to wrinkles and loss of facial firmness. This process begins in our 20s, and is affected by both hereditary influences and environmental factors such as sun exposure, smoking, and stress. WHAT HAPPENS AS WE AGE?
What causes the appearance of aging in hands? As people age, the volume of their hands may shrink, making the veins, tendons, and bones more noticeable. This can lead to an aged appearance. What are “cupid bow” lips? The "cupid's bow" is the iconic double curve in the upper lip, resembling the bow of Cupid, the Roman god of love. The upper lip is thought to be ideal when distinctively formed and symmetrical. Everyone's lip shape and size is unique, and Restylane Silk offers customized shaping and contour precision for silkier, smoother lips and a more natural look. How long do Restylane treatments last? Patients can enjoy lasting effects with full treatment up to 18 months in nasolabial folds with Restylane, up to 12 months in cheeks with Restylane Lyft, 6 months in lips and perioral rhytids with Restylane Silk, and up to 12 months in facial wrinkles and folds with Restylane Refyne and Defyne.10-13 In clinical trials, the results of Restylane Silk typically lasted up to 6 months post-treatment. As demonstrated by a US clinical trial of mostly female subjects (n=221), 98% noted an observable improvement of both upper and lower lip fullness two weeks after injection, while 77% still experienced an enhancement at the 6-month mark.11 In a trial of 150 participants, evaluators noted that 90% showed an improvement of midface fullness after two months of treatment with Restylane Lyft, and 54% still displayed improvement after 12 months. Satisfaction with midface appearance was high, with 95% of trial members pleased after two months and 73% at 12 months.3 Further, a trial of 89 individuals saw an 86% improvement in the volume of the back of their hands at 3 months; this response rate decreased to 76% at 6 months.3 Evaluators used Merz Hand Grading Scale (MHGS) scores to measure improvement, which was defined as participants having achieved a score of ≥1 at the blinded evaluator's live assessment. *n=85 subjects treated. Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.10 Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.12,14,15 A randomized, evaluator-blinded multicenter trial was conducted to assess the longevity of Restylane's NLF correction. Results indicated Restylane provided 18 months of efficacy with retreatment at four-and-a-half or nine months. How long does it take Restylane treatments to work? Most Restylane treatments require less than an hour and start to take effect rapidly as it adds volume to even out wrinkles. Composed of hyaluronic acid in a transparent gel, Restylane products mimic the hyaluronic acid found in the body and gradually deteriorate naturally. They all have a unique purpose. How much do Restylane treatments cost? Price varies based on multiple variables: # of treatment sessions, amount of Restylane used per session, degree of correction identified by clinician & patient, specialist fees, discounts & promotions, & regional market. Feasible cost projections can be accurately estimated after consulting with a specialist, as costs may vary depending on each person's individual needs. Discounts and incentives may be offered periodically through Galderma and/or your aesthetic specialist. Ask your specialist if there are any current programs when you schedule your consultation. We strongly encourage enrolling in ASPIRE Galderma Rewards, our loyalty program that grants you exclusive points and rewards for any aesthetic treatment from the Restylane family. What are the side effects of Restylane products? Patients may experience mild side effects such as swelling, redness, pain, bruising, headaches, tenderness, lump formation, itching, and impaired hand function following injection with Restylane Defyne™. These effects generally last under 7 days in nasolabial folds and up to 14-18 days in the lips. A limit of 6.0 mL per treatment is recommended for the treatment of moderate to severe facial wrinkles and folds, and 3.0 mL per hand is advised for volume deficit in the hands. Swelling may be more likely in individuals under 36 years, and bruising more likely in those over 35 years. Be sure to review Important Safety Considerations prior to using any Restylane products. Are there any before and after pictures of Restylane results? Explore the stunning results of Restylane Silk, Lyft, Refyne, and Defyne procedures with our gallery of before-and-after photos. How many treatments of Restylane products are needed? Initial Restylane treatments may require one or two sessions, as desired. Your body chemistry will be assessed with your healthcare provider to establish an adequate maintenance regimen. It is wise to speak to your physician or healthcare professional to evaluate your individual needs. For convenience, you can also locate a specialist nearby. Can I buy Restylane products online? Restylane products are only available through a physician or experienced healthcare provider. Look for a provider near you for Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne, and Restylane Defyne injections. Who should not use Restylane products? People who are pregnant, breastfeeding, or under 22 should not use Restylane products; and the same applies to those who've taken drugs to reduce clotting, had bad allergies to gram-positive bacteria, serious allergies to medications requiring in-hospital treatment, bleeding disorders, or an allergy to lidocaine if using Restylane Silk, Restylane lyft, Restylane, Restylane Refyne, or Restylane Defyne. Are rebates available on Restylane products? Rebates and treatment discounts are at the discretion of your local healthcare professional or med spa. However, we invite you to join our loyalty program — ASPIRE Galderma Rewards — to earn rewards, bonuses and discounts for any and all Galderma aesthetic treatments for face and hands, including Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne and Restylane Defyne! Just be sure to ask your healthcare professional if his or her practice is part of the ASPIRE Galderma Rewards program. Are there any reasons why I should not use products within the Restylane® family? (Contraindications) Your physician may evaluate your medical history to determine if Restylane Defyne™ is safe and suitable for you. Refrain from using Restylane products if you have experienced severe allergic reactions (anaphylaxis), are allergic to lidocaine or have a sensitivity to the bacterial proteins used to manufacture hyaluronic acid, or have been diagnosed with a bleeding disorder. Are there other precautions that I should discuss with my doctor?
What are the possible side effects? Mild side effects such as swelling, redness, pain, bruising, headache, tenderness, lumps, itching, and impaired hand function are commonly seen and tend to resolve in 7 days or less for nasolabial folds and 14 days or less for lips. Rare but serious side effects may include delayed infections, herpes recurrence, and skin necrosis. Unintentional blood vessel injection is a rare risk, but can lead to serious, potentially permanent complications such as vision loss, stroke, scabs, and scarring. As with all skin injection procedures, there is a risk of infection. To report a side effect with any of the Restylane products, please call Galderma Laboratories, L.P. at 1-855-425-8722. The Restylane family of products is available only through a licensed practitioner. Complete Instructions for Use are available at www.RestylaneUSA.com. |
Treatment Type | Filler, Injectables |
Treatment Problem or Condition | Facial Volume Loss, Fine Lines, Wrinkles |
Size | 1 cc syringe |
Brand | Restylane |
You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).
You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).
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